CS Bio

CSBIO II FEATURES
PERFECT FOR USERS LOOKING TO MAKE R&D PEPTIDE.
- with 150mg Resin, to produce 50 to 500mg crude peptide
- 15ml disposable filtered reaction vessel
- Heated RV and pre-heated solvent delivery
- Thirty 5ml amino acid positions
- 4L, 1L, and 250ml solvent reservoirs
- 2.5L of solvent consumption per synthesis for a 20-mer peptide



CS136X / CS136M
IDEAL FOR R&D, PROCESS DEVELOPMENT OR SMALL-SCALE MANUFACTURING
- 20 – 200mL Reaction Vessel Size
- CS136 has a range of 0.1 to 4mmol.
- Translating to about 100mg to 7g of starting resin.
- Twenty-Two 100mL Amino Acid Reservoirs
- One 5L, four 2L, two 1L and two 250ml solvent reservoirs
- 180° Inversion mixing with nitrogen bubbling for complete solvent and resin contact
- Unlimited couplings, fully automated synthesis of sequences 130-mer or more with no user interaction
- Additional functional reaction vessels (up to 3)
- Heated synthesis with jacketed reaction vessels up to 90°C
- Additional solvent / amino acid reservoirs
- UV monitoring


CS536X / CS936S (PILOT SCALE)
- Our pilot scale instruments enable the user to make high purity peptide at the gram scale.
- The 536X with reaction vessels from 200mL to 2000mL
- The 936S with reaction vessels from 2 to 5L
- Typically to be used for toxicological studies, PK studies, formulation work, additional assay testing or simply just to synthesize larger batches.
- Fully validated software for process development or cGMP production
- Suitable for tBoc Fmoc or any other peptide chemistry
- Flow-through capabilities
- 22 amino acid reservoirs to utilize stock amino acid solutions
- Overhead stirring
- Allowing users to run a synthesis at multiple scales within the same and increase the batch size as their needs and research progress.
- 21 CFR Part 11 Compliant for GMP manufacturing
10-mer* | 35-mer** | |
---|---|---|
CS536X (500mL) |
25mmol |
08mmol |
CS936s (2000mL) |
100mmol |
33mmol |
*Subsitution = 1mmol/g. Resin Growth = 2x ** Subsitution = 0.5 mmol/g. Resin Growth = 3x |



CS936X (COMMERCIAL SCALE)
- Designed and manufactured to customer specifications.
- Commercial scale peptide synthesizers having the largest installation base of any manufacturer.
- With reaction vessels ranging from 5L to 800L,
- We can meet the needs of any customer requirements for large scale peptide synthesis.
- Systems can be designed to meet ATEX, NEC, and additional regional hazardous environment standards.
- This includes the use of all explosion proof equipment for explosive gas atmospheres in the hazardous location, the include motors, sensors, thin clients, etc.
- Our systems can be designed to accommodate your factory depending on the use of a safe room for electrical components, or the use of a purged enclosure.
- Support with DQ, FAT, IQ/OQ.
- Fully validated software for process development or cGMP production.
- 21 CFR Part 11 Compliant for GMP manufacturing
- Available with both CSBio CSPEPM and Rockwell Automation Control system
- Also, guide users through lab setup and pass on industry tips and tricks learned from in house cGMP and R&D synthesis, which is invaluable for those entering the pilot space for the first time.
10-mer* | 35-mer** | |
---|---|---|
CS936 (20L) |
1000mmol |
333mmol |
CS936X (100L) |
5000mmol |
1666mmol |
CS936X (400L) |
25000mmol |
8300mmol |
*Subsitution = 1mmol/g. Resin Growth = 2x ** Subsitution = 0.5 mmol/g. Resin Growth = 3x |