CS Bio

CSBIO II FEATURES

PERFECT FOR USERS LOOKING TO MAKE R&D PEPTIDE.

  • with 150mg Resin, to produce 50 to 500mg crude peptide
  • 15ml disposable filtered reaction vessel
  • Heated RV and pre-heated solvent delivery
  • Thirty 5ml amino acid positions
  • 4L, 1L, and 250ml solvent reservoirs
  • 2.5L of solvent consumption per synthesis for a 20-mer peptide

CS136X / CS136M

IDEAL FOR R&D, PROCESS DEVELOPMENT OR SMALL-SCALE MANUFACTURING

  • 20 – 200mL Reaction Vessel Size
  • CS136 has a range of 0.1 to 4mmol.
  • Translating to about 100mg to 7g of starting resin.
  • Twenty-Two 100mL Amino Acid Reservoirs
  • One 5L, four 2L, two 1L and two 250ml solvent reservoirs
  • 180° Inversion mixing with nitrogen bubbling for complete solvent and resin contact
  • Unlimited couplings, fully automated synthesis of sequences 130-mer or more with no user interaction
  • Additional functional reaction vessels (up to 3)
  • Heated synthesis with jacketed reaction vessels up to 90°C
  • Additional solvent / amino acid reservoirs
  • UV monitoring

CS536X / CS936S (PILOT SCALE)

  • Our pilot scale instruments enable the user to make high purity peptide at the gram scale.
  • The 536X with reaction vessels from 200mL to 2000mL
  • The 936S with reaction vessels from 2 to 5L
  • Typically to be used for toxicological studies, PK studies, formulation work, additional assay testing or simply just to synthesize larger batches.
  • Fully validated software for process development or cGMP production
  • Suitable for tBoc Fmoc or any other peptide chemistry
  • Flow-through capabilities
  • 22 amino acid reservoirs to utilize stock amino acid solutions
  • Overhead stirring
  • Allowing users to run a synthesis at multiple scales within the same and increase the batch size as their needs and research progress.
  • 21 CFR Part 11 Compliant for GMP manufacturing
10-mer* 35-mer**
CS536X (500mL)

25mmol
(17.5g Crude Peptide)

08mmol
(24g Crude Peptide)
CS936s (2000mL)

100mmol
(70g Crude Peptide)

33mmol
(99g Crude Peptide)
*Subsitution = 1mmol/g. Resin Growth = 2x
** Subsitution = 0.5 mmol/g. Resin Growth = 3x

CS936X (COMMERCIAL SCALE)

  • Designed and manufactured to customer specifications.
  • Commercial scale peptide synthesizers having the largest installation base of any manufacturer.
  • With reaction vessels ranging from 5L to 800L,
  • We can meet the needs of any customer requirements for large scale peptide synthesis.
  • Systems can be designed to meet ATEX, NEC, and additional regional hazardous environment standards.
  • This includes the use of all explosion proof equipment for explosive gas atmospheres in the hazardous location, the include motors, sensors, thin clients, etc.
  • Our systems can be designed to accommodate your factory depending on the use of a safe room for electrical components, or the use of a purged enclosure.
  • Support with DQ, FAT, IQ/OQ.
  • Fully validated software for process development or cGMP production.
  • 21 CFR Part 11 Compliant for GMP manufacturing
  • Available with both CSBio CSPEPM and Rockwell Automation Control system
  • Also, guide users through lab setup and pass on industry tips and tricks learned from in house cGMP and R&D synthesis, which is invaluable for those entering the pilot space for the first time.
10-mer* 35-mer**
CS936 (20L)

1000mmol
(700g Crude Peptide)

333mmol
(999g Crude Peptide)
CS936X (100L)

5000mmol
(3500g Crude Peptide)

1666mmol
(4998g Crude Peptide)
CS936X (400L)

25000mmol
(17.5Kg Crude Peptide)

8300mmol
(24.9K Crude Peptide)
*Subsitution = 1mmol/g. Resin Growth = 2x
** Subsitution = 0.5 mmol/g. Resin Growth = 3x